✦ LIBER ✦

The labelling with tritium of 2-(dimethylamino)ethanol and of some drugs containing the 2-(dimethylamino)ethyl group as a structural part

✍ Scribed by W. Hespe; W. Th. Nauta

Publisher: John Wiley and Sons
Year: 1966
Tongue: French
Weight: 235 KB
Volume: 2
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590020207

No coin nor oath required. For personal study only.

✦ Synopsis

Orphenadrine hydrochloride and a related ether were labelled with tritium in the 2-(dimethylamino)-ethyl moiety, by reduction of the corresponding amides with tritiated lithium aluminium hydride (yields 72 and 51 %, resp., specijic radioactivity .57,8 ni Clg in both cases). Hydrolysis of one of the labelled ethers afforded tritiated 2-(dimethylamino) ethanol (yield 80 %, specific radioactivity 146 m Clg). * According to the manufacturer, New England Nuclear Corp., Boston, Mass., U S A , ** We thank Dr. C. van der Stelt for his suggestion to use this route in the synthesis o f this formula represents the structure o f the majority o f labelled molecules. the tritiated ether required.

📜 SIMILAR VOLUMES

A Pentanuclear Cu/Co/Ni Complex with 2-(

A Pentanuclear Cu/Co/Ni Complex with 2-(Dimethylamino)ethanol – Observation of a Rare Molecular Structure Type and Its Place in General Structural Types: An Analysis of the Cambridge Structural Database

✍ Dmytro S. Nesterov; Vladimir N. Kokozay; Brian W. Skelton 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

Metal Complexes with Macrocyclic Ligands

Metal Complexes with Macrocyclic Ligands. Part XXXII. Reactivity studies of the pendant carboxylic group in a macrocyclic Cu2+ complex towards amide formation and its use as a protein-labelling agent

✍ Martin Studer; Thomas A. Kaden; Helmut R. Mäcke 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 German ⚖ 344 KB 👁 1 views

On Polychalcogenides of Thallium with M2

On Polychalcogenides of Thallium with M2Q11 Groups as a Structural Building Block. Part 2. Tl4Ta2Se11: Synthesis, Crystal Structure, Properties and Spectroscopic Investigations of the First Polyselenide Being Composed of a Discrete [Ta2Se11]4- Anion.

✍ Christoph L. Teske; Nicolai Lehnert; Wolfgang Bensch 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 67 KB 👁 2 views

ChemInform Abstract: 1H and 13C NMR Stru

ChemInform Abstract: 1H and 13C NMR Structural Studies on Cellulose and Polysaccharide Derivatives with Carbonyl Groups as a Sensitive Probe. Part 12. Pullulan Nonaacetate: Assignment of Chemical Shifts of the Acetyl Protons and Acetyl Carbonyl Carbons by 2D-NMR Spectroscopy.

✍ Y. TEZUKA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views