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The Kinetics of Interleukin-6 Induction by the Systemic Administration of rhTNF-α in Mice

✍ Scribed by J. K. McINTOSH; J. J. MULÉ; D. M. JABLONS; R. P. NORDAN; S. RUDIKOFF; M. T. LOTZE; S. A. ROSENBERG


Book ID
119863273
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
169 KB
Volume
557
Category
Article
ISSN
0890-6564

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Administration of concanavalin A (Con A) is a well-established model of acute immune-mediated hepatitis. Here, we demonstrate that intravenous injection of Con A in mice induces profound thymic atrophy. Compared to liver damage, the kinetics of Con A-induced thymic atrophy is slower and more prolong