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The Kinetics of Association and Phosphorylation of IκB Isoforms by IκB Kinase 2 Correlate with Their Cellular Regulation in Human Endothelial Cells

✍ Scribed by Heilker, Ralf; Freuler, Felix; Vanek, Miroslava; Pulfer, Ruth; Kobel, Tanja; Peter, Jürg; Zerwes, Hans-Günter; Hofstetter, Hans; Eder, Jörg


Book ID
124153410
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
165 KB
Volume
38
Category
Article
ISSN
0006-2960

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This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of