Activation and regulation of the IκB kin
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Yoko Kosaka; David M. Calderhead; Eric M. Manning; John E. Hambor; Amelia Black;
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Article
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1999
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John Wiley and Sons
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English
⚖ 162 KB
👁 1 views
This study demonstrates that the engagement of CD40 results in the activation of the recently described I O B kinase (IKK) in a human B cell line. The kinase appears to reside within the cell in a cytosolic signalsome complex consisting of IKK, I O B, and an MKP-1-like molecule. While the binding of