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The kinetics and mechanism of aqueous cleavage of imide bond in 5, 5-diethyl barbituric acid (5, 5-diethyl-2,4,6-(1H, 3H) pyrimidinetrione) in a highly alkaline medium

✍ Scribed by M. Niyaz Khan; A. Aziz Khan

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 411 KB
Volume: 16
Category: Article
ISSN: 0538-8066
DOI: 10.1002/kin.550161102

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✦ Synopsis

The kinetic study of alkaline hydrolysis of 5,5-diethyl barbituric acid has been carried out at various [OH] and different temperatures ranging from 85-95°C. The reaction follows a n irreversible first-order consecutive reaction path of the type A *lobs B % X under pseudo-first-order kinetic conditions. A, B, and X represent for 5, 5-diethyl barbituric acid, diethyl malonuric acid, and ammonia, respectively. The pH-rate profiles obtained at three different temperatures reveal distkct phases which are attributed to a change in rate-determining step with change in [OH]. On the basis of the observed data, a possible mechanism has been discussed.

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