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The K+ liquid ion exchange electrode system: Responses to drugs and neurotransmitters

✍ Scribed by T. Kuramoto; Dr. B. Haber

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
700 KB
Volume
6
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

K^+^ ‐sensitive liquid ion exchange electrode systems respond with a slow potential change to acetylcholine, choline, anticholinergic drugs, biogenic amines, and glutamic acid. The response threshold has been defined, and in most cases it is at extremely low concentrations (10^−7^–10^−;5^ M). The direction of the potential change varies, but in most instances it is additive to that produced by external K^+^. The K^+^ electrode system is further sensitive to decreasing pH, within a narrow and possibly physiological range of pH. These findings suggest that small measured changes in extracellular K^+^ are biased by the chemosensitivity of the liquid ion exchange electrode system to some compounds of physiological importance.

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