THE ISOLATION OF A RECEPTOR FOR ADENOSINE 3′,5′-CYCLIC MONOPHOSPHATE (cAMP) FROM THE ADRENAL CORTEX: THE ROLE OF THE RECEPTOR IN THE MECHANISM OF ACTION OF cAMP
✍ Scribed by Leonard D. Garren; Gordon N. Gill; Gordon M. Walton
- Book ID
- 114879506
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 753 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0890-6564
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Adenyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE) have been studied in muscle from patients affected with muscular and neuromuscular diseases as well as in muscle of rats after experimental denervation. A diminution of AC was observed in Duchenne's dystrophy, in neurogenic atrophies,
Rates of synthesis of cyclic 3',5'-adenosine monophosphate (cAMP) were measured in cultures of Escherichia coli aerating without a carbon source. This technique provides a representative measure of adenylate cyclase activity in the absence of inhibition caused by transport of the carbon source. Aden