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The ischaemic leg as a source of complement activation

✍ Scribed by Dr. A. Bengtson; Pia Holmberg; M. Heideman

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
479 KB
Volume
74
Category
Article
ISSN
0007-1323

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✦ Synopsis

Abstract
Complement activation before and after surgical resection was studied in 40 patients with ischaemic legs (17 with acute and 23 with chronic ischaemia). Plasma anaphylatoxin concentrations (C3a and C5a) and anaphylatoxin inhibitor (AI) activity were studied pre-operatively, and 1h, 24 h and 1 week postoperatively. Increased plasma anaphylatoxin concentrations were found pre-operatively. Anaphylatoxin levels in plasma had returned to normal one week postoperatively. Patients with acute ischaemia had higher plasma C3a and C5a pre-operatively and during the first 24 h postoperatively than patients with chronic ischaemia. Anaphylatoxins increase vascular permeability, smooth muscle contraction and histamine release from mast cells. Their enhanced activity might be one of the explanations for respiratory, hepatic and renal insufficiency before surgical resection in patients with extensive ischaemia.

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✍ K. A. Myers; R. B. King; D. F. Scott; N. Johnson; P. J. Morris πŸ“‚ Article πŸ“… 1978 πŸ› John Wiley and Sons 🌐 English βš– 690 KB

## Abstract The salvage rates in 437 severely ischaemic legs (384 patients) treated by arterial reconstuction or by lumbar sympathectomy were studied by the life table method. The results were analysed in the surviving patients. Following arterial reconstruction, the salvage rate was 70 per cent a