An in vitro investigation of the action
An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels
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Cheung Helen; Dietgard Kamp; Eric Harris
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Article
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1992
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Elsevier Science
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English
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Lamotrigine (LTG), 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, is a novel antiepieptic drug structurally unrelated to the major anticonvulsants in current use. Previous studies of LTG in rodents revealed efficacy in maximal electroshock test, pentylenetetrazol test and kindling models of seiz