The Ion Tag Strategy as a Route to Highly Efficient Organocatalysts for the Direct Asymmetric Aldol Reaction

A New Robust and Efficient Ion-Tagged Pr

A New Robust and Efficient Ion-Tagged Proline Catalyst Carrying an Amide Spacer for the Asymmetric Aldol Reaction

✍ Elisa Montroni; Shrihari P. Sanap; Marco Lombardo; Arianna Quintavalla; Claudio 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB

## Abstract The synthesis of a new, highly efficient __cis__‐ion‐tagged catalyst (**8a**), possessing an amide linkage between the imidazolium tag and the proline ring, is described. This new bench‐stable catalyst has been tested in the classic asymmetric aldol condensation between ketones and alde