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The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites

✍ Scribed by Richard G. Titus; Barbara Sherry; Anthony Cerami

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
477 KB
Volume
12
Category
Article
ISSN
0167-5699

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✦ Synopsis

One early reaction of the host to infection with protozoan parasites is the secretion of an array of potent cytokines including tumor necrosis factor (TNF), interleukin (IL-1) and IL-6. The combined action of these cytokines causes fever, leukocytosis and the production of acute phase proteins such as C-reactive protein (CRP). These early responses contribute significantly to the outcome of infection by influencing the course of infection directly and by regulating the specific immune response to the parasite.

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