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The Involvement of a Na + - and Cl – -Dependent Transporter in the Brain Uptake of Amantadine and Rimantadine

✍ Scribed by Kooijmans, Sander A. A.; Senyschyn, Danielle; Mezhiselvam, Muguntha M.; Morizzi, Julia; Charman, Susan A.; Weksler, Babette; Romero, Ignacio-Andres; Couraud, Pierre-Olivier; Nicolazzo, Joseph A.

Book ID
118029447
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
353 KB
Volume
9
Category
Article
ISSN
1543-8384

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Rxt1, a transporter-like protein structurally related to the large family of Na ؉ /Cl ؊ -dependent carriers, was isolated from the rat brain. In the present study, Hxt1, the homologue of Rxt1, was isolated from human cortex cDNA. Comparison of their respective nucleotidic sequences revealed a 96% co