๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The intramolecular nitrile oxide-olefin [3+2] cycloaddition route to the maytansinoids

โœ Scribed by Pat N. Confalone; Soo S. Ko

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
223 KB
Volume
25
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

The macrocyclisation of the olefinic nitrile oxide 24 to the ansa-macrolide skeleton 26, a model for a novel approach to the maytansinoids. is described.

๐Ÿ“œ SIMILAR VOLUMES

The intramolecular nitrile imine cycload
The intramolecular nitrile imine cycloaddition route to pyrazolo[1,5-a][1,4]benzodiazepines
โœ Luca Bruchรฉ; Gaetano Zecchi ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 317 KB

A synthetic route to the title ring system is described, which starts from isatoic anhydride and allylamines, and involves as the key step an intramolecular nitrile imine cycloaddition. The simultaneous formation of two new rings, often accompanied by a high degree of regio-and stereo-selectivity, m

The 1,3-Dipolar Cycloadditions of Nitril
The 1,3-Dipolar Cycloadditions of Nitrile Oxides and Nitrile Imines to Alkyl Dicyanoacetates
โœ Richard Neidlein; Zhihua Sui ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 561 KB

## Abstract The readily available alkyl dicyanoacetates 1 reacted with the 1,3โ€dipolar reagents arenecarbonitrile oxides 2โ€ฒ and arenecarbonitrile imines 5โ€ฒ to afford 1,2,4โ€oxadiazol and 1,2,4โ€triazol derivatives. The arenecarbonitrile oxides 2โ€ฒ with electronโ€donating groups on the arene ring gave p

Fused pyrazolo heterocycles: intramolecu
Fused pyrazolo heterocycles: intramolecular [3+2]-nitrile oxide cycloadditions applied to syntheses of pyrazolo [3,4-g] [2,1] dihydrobenzoisoxazol (in) es
โœ Darin E. Kizer; R.Bryan Miller; Mark J. Kurth ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 174 KB

A general method is described to prepare pyrazolo [3,4-g]-[2,1]dihydrobenzoisoxazol(in)es utilizing intramolecular nitrile oxide cycloaddition (INOC) as the key step. ยฉ1999El~vierScienceLtd. Allfi~ ~serv~.