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The intracellular voyage of cholera toxin: going retro

✍ Scribed by Wayne I. Lencer; Billy Tsai


Book ID
113931044
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
672 KB
Volume
28
Category
Article
ISSN
0968-0004

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The intracellular pathway following receptor-mediated endocytosis of cholera toxin was studied using brefeldin A (BFA), which inhibited protein secretion and induced dramatic morphological changes in the Golgi region. In both mouse Y1 adrcnal cells and CHO cells, BFA at 1 pgiml caused a 80-90% inhib