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The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

โœ Scribed by Ting-Yu Chen; Pei-Hsueh Liu; Chi-Tun Ruan; Ling Chiu; Fan-Lu Kung


Book ID
116292349
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
196 KB
Volume
342
Category
Article
ISSN
0006-291X

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We hypothesized that the physical interaction between the amyloid precursor protein (APP) and Notch 1 (N1) may be mediating the reported cross-talk between the respective signaling pathways. Immunoprecipitation of mouse N1 (mN1) or extracellular domain truncated mN1 (mN1-TM, mimics TACE-produced mem