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The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

✍ Scribed by Youngnam N. Jin; Gail V. W. Johnson


Book ID
106402479
Publisher
Springer US
Year
2010
Tongue
English
Weight
246 KB
Volume
42
Category
Article
ISSN
0145-479X

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Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially degenerate in Huntington's disease, with the presence