The interrelation between brain PO2 and NADH oxidation-reduction state in the gerbil

✍ Scribed by A. Mayevsky; S. Lebourdais; Dr. B. Chance

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 541 KB
• Volume: 5
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490050302

✦ Synopsis

The present investigation was aimed at studying the interrelation between hemodynamic, metabolic and oxygen tension in the brain of the gerbil exposed to various physiological and pathological conditions in the awake and anesthetized states. The hemodynamic and metabolic activities were evaluated by the DC fluorometer/reflectometer and were correlated to the p 0 2 values obtained by a surface electrode.

When the awake brain was exposed to spreading depression (SD), a typical oxidation cycle of the NADH was recorded concomitant with a decrease cycle of the p 0 2 . Under anesthetic effect the same dip in pOz response was found but the NADH showed a "reduction cycle." The PO, values were in a very good correlation with the changes in the reflectance trace, namely, the p 0 2 was a good indicator of the vasoconstriction-vasodilatation responses under various conditions. The same model was used under hypoxic and ischemic conditions, as well as under the effects of anesthetics.