The interactions of triethyltin with rat glutathione-S-transferases A, B AND C. enzyme-inhibition and equilibrium-dialysis studies
β Scribed by Edward Tipping; Brain Ketterer; Lucia Christodoulides; Barry M. Elliott; W. Norman Aldridge; James W. Bridges
- Book ID
- 113136039
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 735 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0009-2797
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## Abstract The haloacetonitrile, dibromoacetonitrile (DBAN), is a directβacting genotoxic agent that has been detected in drinking water. In a time course study, male SpragueβDawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr after treatment. In a dose response stu
Fisher-344 male rats were fed 1.6 ppm of aflatoxin B 1 (AFB 1 ) continuously and intermittently for several weeks. At various time periods, DNA was isolated from the testes and livers and analyzed for AFB 1 -DNA adducts. The ability of the testis to detoxify AFB 1 was also investigated by the glutat