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The interaction of transcription factors with nucleosomal DNA

✍ Scribed by Jeffrey J. Hayes; Alan P. Wolffe

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
844 KB
Volume
14
Category
Article
ISSN
0265-9247

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✦ Synopsis

Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot hind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone-DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory factors bound at dispersed sites into juxtaposition.

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