The interaction of rhodium(III) with DNA by circular dichroism studies. Comparative behaviour of dimethyltin(IV) and thallium(I)

✍ Scribed by Aglaia Koutsodimou; Nikos Katsaros; Dimitra Kovala-Demertzi

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 444 KB
• Volume: 19
• Category: Article
• ISSN: 0340-4285
• DOI: 10.1007/bf00139088

✦ Synopsis

The effect of RhC13 on DNA helix conformation was studied by circular dichroism spectroscopy and compared to the behaviour of Me2SnCI2 and TINO3; the latter metal-DNA systems have been further studied by ultraviolet and thermal denaturation techniques. Both rhodium(III) and tin(IV) react with the bases of DNA and induce appreciable alterations of the double-helical conformation. Rhodium(III) at low binding ratio causes a stabilization of the DNA B conformation, while at higher structural changes are interpreted in terms of a B to C transition. Tin(IV) produces a ~p form geometry; only at high binding ratios does interaction with the phosphate groups seem to occur. The data for thallium(I) are interpreted in terms of a preferential interaction with the phosphate groups of the DNA chain, causing a stabilization of the double-helical structure of DNA.

* Author to whom all correspondence should be directed. this field ~16), we report here the conformational changes of DNA induced by ions with promising anticancer activity such as rhodium(III), dimethyltin(IV) and thallium(I).