The interaction of phospholipase a with lipids. I. Structure of the bimolecular leaflet of a lecithin analogue substance, 1-oleoyl-2-n-hexadecyl-2-deoxyglycero-3-phosphorylcholine
✍ Scribed by W. Lesslauer; A.J. Slotboom; G.H. De Haas
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- English
- Weight
- 992 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
Oriented multilayer systems were prepared with a chemical analogue of lecithin, 1-oleoyl-2-nhexadecyl-2-deoxyglycero-3-phosphorylcholine and studied by X-ray diffraction. Diffraction patterns were recorded with specimens equilibrated in atmospheres of varying relative humidity. Two distinct types, the high and the low humidity diffraction patterns, were observed. At high humidities the multilayers show normal swelling behaviour which is used in the analysis. A bilayer structure with headgroup peaks and a hydrocarbon region is derived from the Fourier synthesis. At low humidity a bilayer in a state of higher order is observed. Two peaks are resolved in the headgroup region. Chain segments in the hydrocarbon region are packed in a lattice at low humidity.