The interaction of Insulin-like Growth Factors (IGFs) with Insulin-like Growth Factor Binding Proteins (IGFBPs): a review
β Scribed by Francine E. Carrick; John C. Wallace; Briony E. Forbes
- Book ID
- 110346676
- Publisher
- Springer Netherlands
- Year
- 2001
- Tongue
- English
- Weight
- 404 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1573-3149
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Insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) play an important role in cell growth and differentiation. Clinical and epidemiological studies have indicated that measuring IGFs and IGFBPs in blood has potential implications in assessing growth-related abnormalities and risks o
## Abstract The influence of a human insulinβlike growth factor binding protein, hIGFBPβ1, on the action of IGFs on human osteosarcoma cells was examined. hIGFBPβ1 was found to block binding of IGFs to their receptors on MGβ63 cells and subsequent IGF stimulation of DNA synthesis. Concurrent incuba