The interaction of hepatitis B virus X protein and protein phosphatase type 2 Cα and its effect on IL-6
✍ Scribed by Ji Su Kim; Bo young Rho; Tae Ho Lee; Jae Myun Lee; Se Jong Kim; Jeon Han Park
- Book ID
- 116293805
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 543 KB
- Volume
- 351
- Category
- Article
- ISSN
- 0006-291X
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Interferons (IFNs) and the interferon-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We have reported previously that ISGs, including guanylate binding protein 1 (GBP-1), interferon alpha inducible protein (IFI)-6-16, and IFI-27, inhibit
The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx trans