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The interaction of heparin with human α-thrombin: Effect on the hydrolysis of anilide tripeptide substrates

✍ Scribed by Michael J. Griffith; Henry S. Kingdom; Roger L. Lundblad

Book ID
115704096
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
635 KB
Volume
195
Category
Article
ISSN
0003-9861

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Effect of NaCl on the association of thrombin with heparin
✍ Dr. Genichiro Oshima; Hideki Uchiyama; Kinzo Nagasawa 📂 Article 📅 1986 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 647 KB

The association of heparin with thrombin was investigated by fluorometric titration. A maximum of 25% of the fluorescence of fluorescein-labeled heparin (FTGheparin) was quenched at thrombin saturation in the absence of NaC1. FTGheparin (H) associated tightly with thrombin (T) and the association co