✦ LIBER ✦

The interaction of cyclosporin and calmodulin

✍ Scribed by Robert F. Steiner; Sharon Albaugh

Publisher: Wiley (John Wiley & Sons)
Year: 1990
Tongue: English
Weight: 707 KB
Volume: 29
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.360290612

No coin nor oath required. For personal study only.

✦ Synopsis

The interaction of cyclosporin A and dansyl cyclosporin A with bovine and wheat germ calmodulin has been monitored by measurements of induced changes in dansyl and bound toluidinyl naphthalene sulfonate fluorescence. The interaction is Ca2 +-dependent and 1 : 1. Measurements of the efficiency of radiationless energy transfer from bound dansyl cyclosporin A to an acceptor group located on Cys-27 of wheat germ calmodulin suggest that the primary binding site is not located on the N-terminal lobe (residues 1-65). However, studies with proteolytic fragments of calmodulin indicate that elements of the N-terminal half-molecule (residues 1-77) may be involved in the stabilization of the binding site. The binding of cyclosporin alters the physical properties of calmodulin and, in particular, reduces the localized rotational mobility of a fluorescent probe.

📜 SIMILAR VOLUMES

Butyltins and calmodulin: which interact

Butyltins and calmodulin: which interaction?

✍ Francesca Cima; Debora Dominici; Stefano Mammi; Loriano Ballarin 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

Mechanism of the ketoconazole-cyclospori

Mechanism of the ketoconazole-cyclosporin interaction

✍ Eric Ah-Sing; Thomas W. Poole; Costas Ioannides; Laurence J. King 📂 Article 📅 1990 🏛 Springer-Verlag 🌐 English ⚖ 201 KB

Pharmacokinetic interaction between cycl

Pharmacokinetic interaction between cyclosporin and diltiazem

✍ J. Brockmöller; H.-H. Neumayer; K. Wagner; W. Weber; G. Heinemeyer; H. Kewitz; I 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 683 KB

Previous reports have indicated that administration of the calcium antagonist diltiazem results in major changes in the pharmacokinetics of cyclosporin A (CyA). A new clinical trial was undertaken in 22 renal transplant patients receiving a constant dose of cyclosporin to further explore this intera

Tat peptide-calmodulin binding studies a

Tat peptide-calmodulin binding studies and bioinformatics of HIV-1 protein–calmodulin interactions

✍ Peter McQueen; Lynda J. Donald; Thach N. Vo; Dung H. Nguyen; Heather Griffiths; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 923 KB

## Abstract The human immunodeficiency virus type 1 (HIV‐1) genome encodes 18 proteins and 2 peptides. Four of these proteins encode high‐affinity calmodulin‐binding sites for which direct interactions with calmodulin have already been described. In this study, the HIV‐1 proteome is queried using a

Pediatric clinical use of the ketoconazo

Pediatric clinical use of the ketoconazole/cyclosporin interaction

✍ M. Berkovitch; M. Bitzan; D. Matsui; H. Finkelstein; J. W. balfe; G. Koren 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 217 KB

Chlordecone interaction of calmodulin bi

Chlordecone interaction of calmodulin binding with phosphodiesterase

✍ P. J. S. Vig; D. Desaiah; B. D. Mehrotra 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

The effects of organochlorine (O.C.) compounds, such as aldrin, dieldrin, endrin, isodrin, chlordecone and mirex, on calmodulin (CaM) activity were investigated. Changes induced by O.C. compounds on biological and physical properties of CaM were monitored in terms of phosphodiesterase stimulation an