The interaction index, a novel information-theoretic metric for prioritizing interacting genetic variations and environmental factors

A comprehensive catalogue of functional

A comprehensive catalogue of functional genetic variations in the EGFR pathway: Protein–protein interaction analysis reveals novel genes and polymorphisms important for cancer research

✍ Sevtap Savas; Joseph Geraci; Igor Jurisica; Geoffrey Liu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 640 KB

## Abstract The EGFR pathway is a critical signaling pathway deregulated in many solid tumors. In addition to the initiation and progression of cancer, the EGFR pathway is also implicated in variable treatment responses and prognoses. Genetic variation in the form of Single Nucleotide Polymorphisms