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The interaction between two forms of cytochrome P-450 during drug oxidation in the reconstituted system containing limited amount of nadph-cytochrome P-450 reductase

✍ Scribed by Kitada Mitsukazu; Sakamoto Ken'ichi; Rikihisa Tadaaki; Kanakubo Yoshio


Book ID
115777319
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
698 KB
Volume
33
Category
Article
ISSN
0006-2952

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The concept of relative activity factor (RAF) to extrapolate data obtained with recombinant cytochrome P450(CYP)s to human liver microsomes has been proposed. To evaluate the approach to predict the contribution of multiple CYPs using RAF, we investigated the effects of the differences in the expres