The interaction between sodium outflux and the sodium transport system in the frog skin

✍ Scribed by Kirschner, Leonard B.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1959
• Tongue: English
• Weight: 398 KB
• Volume: 53
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030530109

✦ Synopsis

Quantitative description of the kinetics of active ion movement has usually entailed some use of the diffusion equations. Since these equations are independent of any particular chemical mechanism, they are unlikely to yield information concerning a molecular model of the process. Recently a few attempts have been made to treat ion transport from a different point of view, one which assumes that a chemical reaction involving the ion underlies active transport, 'I'lius, both "carriers" (Kirschner, '55, Kato et al., '56, Snell and Leernan, '57) and "non-carriers" (Patlak, '57) undergo such a reaction.

I n addition to the assumption that a n ion-carrier complex was formed our treatment included a second hypothesis to account for a phenomenon so far described only for the frog skin. When the outside of an isolated skin is bathed by a solution containing little sodium the sodium outflux (Mo)2 is small, When the concentration in the external solution is high (eg., 115 mM/1) M, is much larger (Kirschner, '55). Thus the magnitude of the flux seems to be conditioned by the composition of the solution info which the ions are diffusing.