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The interaction between smoking andGSTM1variant on lung cancer in the Chinese population

✍ Scribed by Zhang, Yanan; Liu, Chibo

Book ID
118302912
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
485 KB
Volume
34
Category
Article
ISSN
1010-4283

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## Abstract Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/