✦ LIBER ✦

The interaction between HPV infection and estrogen metabolism in cervical carcinogenesis

✍ Scribed by Karen J. Auborn; Craig Woodworth; Joseph A. Dipaolo; H. Leon Bradlow

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 428 KB
Volume: 49
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910490611

No coin nor oath required. For personal study only.

✦ Synopsis

Cancer of the genital tract is the final outcome of some infections with human papillomavirus (HPVs), and the most estrogen-sensitive cells are at greatest risk for the HPV-related cancers. Therefore we investigated relationships between HPVs and estrogen metabolism in cells of the genital tract. Increased conversion of estradiol to I6a-hydroxyestrone, known to be a risk factor for cancer in some other estrogen-sensitive cells, was investigated in keratinocytes from the genital tract. Primary cells, particularly those explants from the transformation zone of the cervix, are able to 16a-hydroxylate estradiol. Both cervical and foreskin cells immortalized with HPV-16 are greatly enhanced in the 16~x1-hydroxylation of estradiol as compared with normal cells. We suggest a model whereby the combined action of 16~-hydroxylation of estrogen and HPV work together to promote cell proliferation.

📜 SIMILAR VOLUMES

Gene expression changes during HPV-media

Gene expression changes during HPV-mediated carcinogenesis: A comparison between an in vitro cell model and cervical cancer

✍ Fang Wan; Xijiang Miao; Iram Quraishi; Valerie Kennedy; Kim E. Creek; Lucia Piri 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 1019 KB

## Abstract We used oligonucleotide microarrays to investigate gene expression changes associated with multi‐step human papillomavirus type 16 (HPV16)‐mediated carcinogenesis __in vitro__. Gene expression profiles in 4 early passage HPV16‐immortalized human keratinocyte (HKc) lines derived from dif

Association Between HLA-DRB1 polymorphis

Association Between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese

✍ Paul K.S. Chan; Tak-Hong Cheung; C. K. Lin; Shing-Shun N. Siu; So-Fan Yim; Keith 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 1 views

## Abstract Multiple determinants are involved in the progression of human papillomavirus (HPV)‐infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLA‐DRB1 polymorphism, high‐risk HPV infection, a

Risk factors for HPV infection in women

Risk factors for HPV infection in women from sexually transmitted disease clinics: Comparison between two areas with different cervical cancer incidence

✍ Edith I. Svare; Susanne K. Kjaer; Anne-Marie Worm; Anne Østerlind; Harald Moi; R 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 111 KB 👁 2 views

We have compared risk factors for human papillomavirus (HPV) infection in very sexually active women [attenders of clinics for sexually transmitted diseases (STDs)] living in 2 areas with a 4-fold difference in cervical cancer incidence, i.e., Greenland and Denmark. The results were compared with fi

Interactions between metabolic and repro

Interactions between metabolic and reproductive functions in the resumption of postpartum fecundity

✍ Claudia Valeggia; Peter T. Ellison 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

## Abstract Lactation has long been recognized as a major determinant of interbirth intervals. The temporal pattern of nursing has been proposed as the mechanism behind lactational amenorrhea. We present a new model of the dynamic regulation of lactational amenorrhea that identifies maternal energy

Halting the interaction between vascular

Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice

✍ Hitoshi Yoshiji; Shigeki Kuriyama; Junichi Yoshii; Yasuhide Ikenaka; Ryuichi Nog 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

It has been shown that angiogenesis plays an important role not only in tumor growth, but also in early carcinogenesis. The expression of a potent angiogenic factor, vascular endothelial growth factor (VEGF), increased during the early stage of carcinogenesis. In this study, the effects of the neutr

Bidirectional interactions between the e

Bidirectional interactions between the estrogen receptor and the c-erbB-2 signaling pathways: Heregulin inhibits estrogenic effects in breast cancer cells

✍ Thomas W. Grunt; Miguel Saceda; Mary Beth Martin; Ruth Lupu; Evelyn Dittrich; Ge 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 993 KB

The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/