Using the in situ perfused rat liver model, the effect of erythromycin (Ery) on the disposition of cyclosporin A (CyA) and the major human metabolite, AMl, was investigated. Prior to perfusion experiments, oral dosing was carried out for three days on three groups of male Sprague-Dawley rats (300-35
✦ LIBER ✦
The Interaction between Cyclosporin A and Erythromycin Studied by Means of an Isolated Perfused Rat Liver Model
✍ Scribed by Fabre, Isabelle ;Richard, Bruno ;Combalbert, Jean ;Fabre, Gérard ;Cano, Jean-Paul
- Book ID
- 114801335
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 572 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0901-9928
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Cyclosporin A and erythromycin: A study
✍
C. M. Hughes; J. G. Swanton; P. S. Collier
📂
Article
📅
1993
🏛
John Wiley and Sons
🌐
English
⚖ 560 KB
Dose-dependent inhibition of transporter
✍
Ridhi Parasrampuria; Reza Mehvar
📂
Article
📅
2010
🏛
John Wiley and Sons
🌐
English
⚖ 192 KB
👁 1 views
Methotrexate (MTX) and cyclosporine (CyA) are coadministered in a number of diseases. In this study, the effects of CyA on the hepatobiliary disposition of MTX were investigated in an isolated perfused rat liver model. A bolus 5-mg dose of MTX was added to a recirculating perfusate in the absence or
Influence of hypoxia on the metabolism a
✍
Brian R. Smith; Jerry L. Born; Dennis J. Garcia
📂
Article
📅
1983
🏛
Elsevier Science
🌐
English
⚖ 479 KB
Development and Application of an Isolat
✍
Reza Mehvar; Xiaoping Zhang
📂
Article
📅
2002
🏛
Springer US
🌐
English
⚖ 245 KB
Role of the liver in the degradation of
✍
E. M. BERRY; R. ALDINI; H. BARON; S. EISENBERG
📂
Article
📅
1981
🏛
John Wiley and Sons
🌐
English
⚖ 837 KB
Relaxin as a Protective Substance in the
✍
Markus U. Boehnert; Franz Paul Armbruster; Heidegard Hilbig
📂
Article
📅
2009
🏛
John Wiley and Sons
🌐
English
⚖ 56 KB