The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study
✍ Scribed by L. Wouts; J.G. Janzing; I.K. Lampe; B. Franke; F. de Vegt; I. Tendolkar; M.B. van Iersel; J.K. Buitelaar; R.C. Oude Voshaar
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 160 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0885-6230
- DOI
- 10.1002/gps.2584
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✦ Synopsis
Abstract
Objective
Vascular disease and neuroticism are both risk factors for late‐life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late‐life.
Methods
Multivariate logistic regression in a survey of 1396 population‐dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES‐D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke.
Results
Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4–1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6–0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6–0.96) when predicting CRDS.
Conclusions
In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease. Copyright © 2010 John Wiley & Sons, Ltd.