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The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors

✍ Scribed by Azin Nezami; Ernesto Freire


Book ID
114043434
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
649 KB
Volume
32
Category
Article
ISSN
0020-7519

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High-Affinity Inhibitors of tRNA-Guanine
✍ Philippβ€…C. Kohler; Tina Ritschel; W.β€…Bernd Schweizer; Gerhard Klebe; FranΓ§ois Di πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 529 KB

## Abstract The tRNA‐modifying enzyme tRNA–guanine transglycosylase (TGT) is essential for the pathogenic mechanism of __Shigella flexneri__, the causing agent of the bacterial diarrheal disease shigellosis. Herein, the synthesis of a new class of rationally designed 6‐amino‐imidazo[4,5‐__g__]quina