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The Insulin-Like Growth Factor (IGF) Receptor Type 1 (IGF1R) as an Essential Component of the Signalling Network Regulating Neurogenesis

✍ Scribed by Alexander Annenkov

Book ID: 107582624
Publisher: Springer
Year: 2009
Tongue: English
Weight: 476 KB
Volume: 40
Category: Article
ISSN: 0893-7648
DOI: 10.1007/s12035-009-8081-0

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## Abstract Type 1 insulin‐like growth factor receptor (IGF1R) signaling in neuronal development was studied in mutant mice with blunted __igf1r__ gene expression in nestin‐expressing neuronal precursors. At birth [postnatal (P) day 0] brain weights were reduced to 37% and 56% of controls in mice h