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The InsP3 receptor: its role in neuronal physiology and neurodegeneration

✍ Scribed by Santanu Banerjee; Gaiti Hasan

Book ID
102757527
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
526 KB
Volume
27
Category
Article
ISSN
0265-9247

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✦ Synopsis

The InsP 3 receptor is a ligand-gated channel that releases Ca 2ΓΎ from intracellular stores in a variety of cell types, including neurons. Genetic studies from vertebrate and invertebrate model systems suggest that coordinated rhythmic motor functions are most susceptible to changes in Ca 2ΓΎ release from the InsP 3 receptor. In many cases, the InsP 3 receptor interacts with other signaling mechanisms that control levels of cytosolic Ca 2ΓΎ , suggesting that the maintenance of Ca 2ΓΎ homeostasis in normal cells could be controlled by the activity of the InsP 3 R. In support of this idea, recent studies show that altered InsP 3 receptor activity can be partially responsible for Ca 2ΓΎ dyshomeostasis seen in many neurodegenerative conditions. These observations open new avenues for carrying out genetic and drug screens that target InsP 3 R function in neurodegenerative conditions.

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