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The inhibitory effects of Ro 31-6930 and BRL 38227 on cholinergically-mediated bronchoconstriction in the guinea-pig

✍ Scribed by Paul R. Gater; Peter M. Paciorek; Jennifer C. McKean; Kevin Wilson; Michael Brewster; John F. Waterfall


Book ID
115888614
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
560 KB
Volume
238
Category
Article
ISSN
0014-2999

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Relaxant Effects of the Potassium Channe
✍ D.R. Buckle; J.R.S. Arch; N.E. Bowring; K.A. Foster; J.F. Taylor; S.G. Taylor; D πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier 🌐 English βš– 525 KB

SUMMARY: The airways relaxant effects and mechanism of action of the potassium channel activators BRL 38227 and pinacidil have been compared in guinea-pig and human airways. BRL 38227 was a potent relaxant in guinea-pig isolated trachealis ( \(\mathrm{IC}_{50}=4.9 \times 10^{-7} \mathrm{M}\) against