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The inhibitory effects of ginsenoside and quercetin on oxidative damage by puromycin aminonucleoside in rat

✍ Scribed by Beong Ou Lim; Byung Pal Yu; Jun-Hawn Oh; Dong Ki Park

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 214 KB
Volume: 12
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199808)12:5<375::aid-ptr315>3.0.co;2-f

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✦ Synopsis

This study examined the protective effect of two natural antioxidants, ginsenoside Rb-1 and quercetin, on acute nephrosis induced by puromycin aminonucleoside (PA). The protective action of Rb-1 and quercetin were evidenced by their ability to suppress the formation of phosphatidylcholine hydroperoxide in the plasma, liver and kidney. Another beneficial effect noted from these natural antioxidants was increased glutathione peroxidase activity in the blood. Our results suggest that the severity of PA-induced acute nephrosis can be ameliorated by the antioxidative action of these two flavonoids.

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