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The inhibitory effect of interferon on hepatitis C virus replication is not mediated via nitric oxide in man

✍ Scribed by Akeel Halai; Lynda Ruffini; Gerond Lake-Bakaar


Book ID
119389523
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
33 KB
Volume
95
Category
Article
ISSN
0002-9270

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The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina