The inhibitory activity of a brain extract on synaptosomal Na+,K+-ATPase is sensitive to carboxypeptidase A and to chelating agents

A reduction in the activity of the NA+,

A reduction in the activity of the NA+, K+ -pump in dimethylsulfoxide-treated friend erythroleukemia cells is not due to partial inactivation of the NA+, K+ -ATPase

✍ Andras Schaefer; Karl-Heinz Munter; Peter Geck; Gebhard Koch 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 706 KB

Treatment of Friend-erythroleukemia cells with 1.5% dimethylsulfoxide (DMSO) caused a decrease in ouabain sensitive 86Rb+-uptake beginning six to seven hours after DMSO addition indicating a reduced function of the Na+, K+-pump. However, analysis of the ouabain sensitive 86Rb+-uptake after Na+-prelo