The inhibition of serine proteases by n-peptidyl o-aroyl hydroxylamines—mechanistic investigations by means of semiempirical methods

Investigation of the inhibition pathway

Investigation of the inhibition pathway of glucosamine synthase by N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid by semiempirical quantum mechanical and molecular mechanics methods

✍ M. Tarnowska; S. Oldziej; A. Liwo; Z. Grzonka; E. Borowski 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 595 KB

Glucosamine synthase (E.C. 2.6.1.16) is a promising target in antifungal drug design. It has been reported that its potent inhibitor, N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), inactivates the enzyme by the Michael addition of the S-H group to the FMDP molecule followed by cyclisatio