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The inhibition of DNA repair capacity by stilbene estrogen in Leydig cells: its implications in the induction of instability in the testicular genome

✍ Scribed by James W. DuMond; Deodutta Roy


Book ID
114070482
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
251 KB
Volume
483
Category
Article
ISSN
0027-5107

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Testicular cells of male mice were isolated, and the incorporation of tritium labeled thymidine into the DNA of the cells was estimated after exposure to various chemical mutagens. The normal semiconservative DNA synthesis was suppressed by the addition of hydroxyurea. Thirteen compounds were tested