Interactions and inhibition of blood coa
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Rolf M. Mesters; Mary J. Heeb; John H. Griffin
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Article
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1993
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Cold Spring Harbor Laboratory Press
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English
β 934 KB
## Abstract Activated protein C (APC) exerts its physiologic anticoagulant role by proteolytic inactivation of the blood coagulation cofactors Va and VIIIa. The synthetic peptideβ(311β325) (KRNRTFVLNFIKIPV), derived from the heavy chain sequence of APC, potently inhibited APC anticoagulant activity