The inhibition by naphthoquinones and anthraquinones of 2-amino-3-methylimidazo[4,5-f ]quinoline metabolic activation to a mutagen: a structure-activity relationship study

Mutagenic activation of 2-amino-3-methyl

Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline (MeIQ) by subcellular fractions and cells isolated from small intestine, kidney and liver of the rat

✍ Jørna A. Holme; Jan Alexander; Erik Dybing 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 669 KB

The mutagenic activity of the pyrolysis products 2-amino-3-methylimidazo [4,5-J'\_~quinoline and 2-amino-3, 4-dimethylimidazo[4,5-fJ-quinoline in Salmonella typhimurium TA98 using rat intestinal and renal subcellular fractions as activation systems was approximately 1 and 5 revertants per nmol, resp