The inhibiting effect of PABA on photocarcinogenesis

✍ Scribed by H. Flindt-Hansen; P. Thune; T. Eeg Larsen

• Publisher: Springer-Verlag
• Year: 1990
• Tongue: English
• Weight: 334 KB
• Volume: 282
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00505643

✦ Synopsis

The efficacy of a 5% solution of para-aminobenzoic acid (PABA) to protect against photocarcinogenesis was tested in 6 groups, each of which contained 30 light pigmented hairless mice. The light source was a Phillips TL 40 W]12, which mainly emits UVB. PABA significantly retarded the tumor induction time (p < 0.05) and reduced both tumor yield and carcinoma yield (p < 0.05). The dorsal skin of the mice was removed and weighed. The mean weight of UVR-exposed mice skin protected with PABA did not differ from that of the controls, but in the non-protected UVRexposed mice the skin samples were significantly heavier 60 < 0.05).