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The inheritance of mitochondrial DNA heteroplasmy: random drift, selection or both?

✍ Scribed by Patrick F Chinnery; David R Thorburn; David C Samuels; Sarah L White; Hans-Heinrik M Dahl; Doug M Turnbull; Robert N Lightowlers; Neil Howell

Book ID
114172640
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
209 KB
Volume
16
Category
Article
ISSN
0168-9525

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Leber hereditary optic neuropathy: Does
Leber hereditary optic neuropathy: Does heteroplasmy influence the inheritance and expression of the G11778A mitochondrial DNA mutation?
✍ Chinnery, Patrick F. ;Andrews, Richard M. ;Turnbull, Douglass M. ;Howell, Neil πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 209 KB πŸ‘ 2 views

Leber hereditary optic neuropathy (LHON) is a major cause of inherited blindness in young males. Approximately 1 in 7 individuals with LHON harbor a mixture of mutated and wild-type (normal) mtDNA (heteroplasmy), and the risks of developing blindness in heteroplasmic LHON individuals are not well ch