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The influence ofIgh-1genes on the class and subclass distribution of oxazolone-specific antibodies

✍ Scribed by Glória László; Éva Rajnavölgyi; István Andó; János Gergely

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
954 KB
Volume
21
Category
Article
ISSN
0093-7711

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✦ Synopsis

Previous studies have demonstrated that the level of the oxazolonespecific antibody response induced by contact sensitization is under the control of H-2 and Igh-l-linked genes. The aim of the present study was to clarify the role of H-2 and Igh-1 genes in the regulation of antibody affinity and isotype composition of oxazolone-specific antibodies. Analysis of the antibody response to oxazolone has revealed different ratios of IgG2a and IgG2b antibodies in mice carrying the Igh-1 b allele and in strains carrying alleles a, c, and e. The characteristic ratio of IgG2a and IgG2b isotypes persisted during the whole period of the primary and secondary antibody response of CBA and CBA-Ig b Igh-C congenic mice. The Igh-l-linked genes influenced the isotype distribution and not the affinity of oxazolone-specific antibodies induced by contact sensitization.

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