The influence of α-aryl ethers on the asymmetric reduction of carbonyls

✍ Scribed by William D Samuels; David A Nelson; Richard T Hallen

• Book ID: 104218805
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 204 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84723-1

✦ Synopsis

The asymmetric reduction of a-aryl ethers 1 was found to be strongly influenced bv the uresence of ortho substituents on tFe arvl rina.

tirouos (methoxv or hydroxy) that chelate metal cations tend to stabilize-a "1ockkd"'bicycl;c 4 which, intermediate when reduced, yielded preferentially the erytho isomer.