The influence of vascular space involvement on the prognosis of patients with stage IB cervical carcinoma : Correlation of results from hematoxylin and eosin staining with results from immunostaining for factor VIII-related antigen
✍ Scribed by Andreas Obermair; Christian Wanner; Selcuk Bilgi; Paul Speiser; Klaus Reisenberger; Alexandra Kaider; Christian Kainz; Sepp Leodolter; Gerhard Breitenecker; Gerald Gitsch
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 293 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
staining from the same block in two separate runs. cology and Obstetrics, University Hospital of Vi-
RESULTS.
The median follow-up period was 85 months (range, 5-170 months). enna, Vienna, Austria. The 25% quantile for OS was 109 months (median not reached; range, 5-170 2 Division of Obstetrics, Department of Gynecolmonths). The overall rates of VSI/H & E and VSI/F8 were 29.4% and 24.5%, respecogy and Obstetrics, University Hospital of Vitively. The findings obtained by H & E and F8-RA staining were concurrent in 60.7% enna, Vienna, Austria. of cases. Lymph node involvement and VSI/F8 remained independent prognostic 3 Gynecopathological Unit, Department of Pafactors for DFS and OS. Due to a highly significant correlation of pelvic lymph thology, University Hospital of Vienna, Vienna, node status with both VSI/H & E and tumor size, the last two parameters failed Austria. to retain a significant value. For lymph node negative patients, the estimated OS 4 Department of Medical Computer Sciences/ probability was 92% for those without VSI/F8 and 62% for those with VSI/F8. Biometrics, University Hospital of Vienna, Vi-CONCLUSIONS. VSI/F8 may provide additional information on the outcome of clinienna, Austria. cal Stage IB cervical carcinoma. Lymph node negative patients with VSI/F8 positive tumors may benefit from more intense postsurgical treatment. Further trials involving larger series of patients are necessary to confirm these findings. Cancer