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The influence of topical prostaglandins on HSA-induced uveitis in the rabbit

✍ Scribed by Ph. F. J. Hoyng

Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
263 KB
Volume
73
Category
Article
ISSN
0012-4486

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✦ Synopsis

In this study the effect of topical administration of prostaglandins (PGs) on a human serum albumin (HSA)-induced uveitis is evaluated. Topical prostaglandin E~ (PGE 0 and prostaglandin F2~ (PGF2~) partly inhibited hyperaemia and flare in the anterior chamber after the induction of immune complex uveitis. A marked increase in the cellular response was observed in the aqueous humour after topical PGE l and PGF2~. Topical prostaglandins may decrease endogenous prostaglandin formation and reduce the prostaglandin-mediated inflammatory symptoms; on the other hand, they also stimulate the aqueous cellular response, possibly by facilitation of leukotriene formation.

These results indicate that topical prostaglandins should not be used to treat immunogenic uveitis.

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The therapeutic effect of topically applied prostaglandin inhibitors on the laser4nduced disruption of the blood-aqueous barrier was investigated in six series of five rabbits each. One series was not coagulated and served as baseline, and in a reference group laser coagulation was performed without