The influence of the 4- quinolones ciprofloxacin, pefloxacin and ofloxacin on the elimination of theophylline
β Scribed by Wijnands, W. J. A. ;Vree, T. B. ;Baars, A. M. ;van Herwaarden, C. L. A.
- Publisher
- Springer
- Year
- 1987
- Tongue
- Dutch
- Weight
- 294 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1573-739X
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## Abstract The aim of this study was to determine whether the dose influences the distribution kinetics of ciprofloxacin and ofloxacin in muscleβ boneβ and skinβtissues included in the isolated hindlimb of the rat. Experiments were carried out in the isolated perfused hindlimb of the rat, administ
The effect of placebo or cimetidine at a dose of 1 g daily on theophylline elimination was studied in a double-blind control manner in twelve healthy adult males aged 19-31 years. In a group of six, placebo had no effect on any of theophylline half-life (tb), volume of distribution ( v d ) , and tot