✦ LIBER ✦

The influence of sequential chemotherapy and radiotherapy on mitogen-induced lymphocyte transformation in patients with acute lymphoblastic leukemia

✍ Scribed by Humphrey, G. Bennett ;Parker, Donald E. ;Nesbit, Mark ;Krivit, William

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 463 KB
Volume: 2
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950020104

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Although these studies do not allow a definitive differentiation between the relative influence of chemotherapy and radiotherapy on mitogen‐induced lymphocyte transformation, the data suggested both radiotherapy and chemotherapy can cause depression; however, radiotherapy may have a more pronounced effect. The relationship between the absolute peripheral blood lymphocyte count and phytohemagglutin and pokeweed mitogen‐induced lymphocyte transformation was also analyzed. These data revealed that patients who are receiving or who have received intensive therapy may have normal peripheral absolute lymphocyte counts with impaired lymphocyte transformation. Serial studies of lymphocyte transformation were evaluated in 10 children with acute lymphoblastic leukemia who received both chemotherapy and radiotherapy.

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